Chemla Y, Itzhaki O, Melamed S, Weller C, Sade Y, Manich P, Reshef K, Xenidis N, Maliah A, Levy G, Parikh R, Bartok O, Levy O, Tal I, Aziel G, Nissani A, Yunger S, Likonen D, Kliminsky V, Golan T, Capron C, Ace V, Levy R, Rasoulouniriana D, Eyal Z, Barzilay Y, Balaban R, Khateeb A, Khosravi R, Grau A, Ziv T, Greenberg P, Netanely D, Vaknin H, Wu X, Amitay Y, Brenner R, Martínez Gómez JM, Hershkovitz D, Yardeni T, Zemser-Werner V, Kobiler O, Friedmann Y, Bassan D, Shamir R, Eisenbach L, Santana-Magal N, Milyavsky M, Eisenberg G, Keren L, Cohen M, Gur D, Barak B, Lotem M, Sprinzak D, Greenberger S, Fisher D, Besser MJ, Khaled M, Close P, Shapira R, Apcher S, Madi A, Levesque MP, Rapino F, Carmi Y, Parikh S, Samuels Y, Levy C. HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion.
Cell.  2026;189:1–19. PMID: 41401806 | doi: 10.1016/j.cell.2025.11.020. PDF

Afratis NA, Parikh S, Adir I, Parikh R, Solomonov I, Kollet O, Gelb S, Sade Y, Vaknine H, Zemser-Werner V, Brener R, Nizri E, Hershkovitz D, Ricard-Blum S, Levy C, Sagi I. Biselective remodeling of the melanoma tumor microenvironment prevents metastasis and enhances immune activation in mouse models. Science Translational Medicine. 2025; 17(820):eadp3236. doi: 10.1126/scitranslmed.adp3236. 

Maliah A, Santana-Magal N, Parikh S, Gordon S, Reshef K, Sade Y, Khateeb A, Richter A, Gutwillig A, Parikh R, Golan T, Krissi M, Na M, Binshtok G, Manich P, Elkoshi N, Grisaru-Tal S, Zemser-Werner V, Brenner R, Vaknine H, Nizri E, Moyal L, Amitay-Laish I, Rosemberg L, Munitz A, Kronfeld-Schor N, Shifrut E, Kobiler O, Madi A, Geiger T, Carmi Y, Levy C. Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy.
Nature Communications. 2024;15:8354. doi: 10.1038/s41467-024-52079-x. 

Parikh R., Parikh S., Berzin D., Vaknine H., Ovadia S., Likonen D., Greenberger S., Scope A., Elgavish S., Nevo Y., Plaschkes I., Nizri E, Kobiler O., Maliah A., Zaremba L., Mohan V., Sagi I., Ashery-Padan R., Carmi Y., Luxenburg C., Hoheisel J.D, Khaled M., Levesque M.P and Levy, C. Recycled melanoma-secreted melanosomes regulate tumor-associated macrophage diversification. The EMBO Journal. 2024. doi.org/10.1038/s44318-024-00103-7. PDF

Elkoshi, N., Parikh, S., Malcov-Brog, H., Rarikh, R., Manich, P., Netti, F., Maliah, A., Elkoshi, H., Haj, M., Ebenstein, Y., Shiloh, Y. and Levy, C. ATM signaling delays skin pigmentation upon UV exposure by mediating MITF function towards DNA repair mode. J Invest Dermatol. 2023 in press. PDF

Leichner, SG., Schweitzer, I., Dror, S., Levin, L., Geva, P., Zaremba, L., Hoheisel, JD., Levy, C. and Greenberger, S. Primary melanoma miRNAs trafficking induces lymphangiogenesis. J Invest Dermatol. 2023 in press. PDF

Sarfstein, R., Nagaraj, K., Parikh, S., Levy, C., Laron, Z., Benayahu, D., & Werner, H. 2022. Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action. Cells 2022, 11, 1627.

Zornitzki, T., Tshori, S., Shefer, G., Mingelgrin, S., Levy, C., & Knobler, H. (2022). Seasonal Variation of Testosterone Levels in a Large Cohort of Men. International Journal of Endocrinology, 2022. doi.org/10.1155/2022/6093092

Maliah, A., Parikh, R., Tayer-Shifman, O.E., Kimhi, O., Gepstein, R., Halperin, T., Levy, Y., Levy, C., Basson, Y.P.P. and Kivity, S. Steroid treatment suppresses the CD4+ T-cell response to the third dose of mRNA COVID-19 vaccine in systemic autoimmune rheumatic disease patients.2022. Scientific Reports, 12(1), p.21056. doi.org/10.1038/s41598-022-25642-z PDF

Gutwillig, A., Santana-Magal, N., Farhat-Younis, L., Rasoulouniriana, D., Madi, A., Luxenburg, C., Cohen, J., Padmanabhan, K., Shomron, N., Shapira, G. and Gleiberman, A., Parikh, R., Levy, C., Feinmesser, M., Hershkovitz, D., Zemser-Werner, V., Zlotnik, O., Kroon, S., Hardt, WD., Debets, R., Reticker-Flynn, NE., Rider, P. and Carmi, Y. Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy. 2022 Dec. eLife 11:e80315 doi.org/10.7554/eLife.80315

Sheinboim D, Parikh S, Manich P, Markus I, Dahan S, Parikh R, Stubbs E, Cohen G, Zemser-Werner V, Bell RE, Ruiz SA, Percik R, Brenner R, Leibou S, Vaknine H, Arad G, Gerber Y, Keinan-Boker L, Shimony T, Bikovski L, Goldstein N, Constantini K, Labes S, Mordechai S, Doron H, Lonescu A, Ziv T, Nizri E, Choshen G, Eldar-Finkelman H, Tabach Y, Helman A, Ben-Eliyahu S, Erez N, Perlson E, Geiger T, Ben-Zvi D, Khaled M, Gepner Y, Levy C. An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination. Cancer Research. 2022 Nov 15;82(22):4164-4178. doi: 10.1158/0008-5472.CAN-22-0237. PMID: 36084256. Selected for Cancer Research cover, November 2022. PDF

Parikh S, Parikh R, Michael K, Bikovski L, Barnabas G, Mardamshina M, Hemi R, Manich P, Goldstein N, Malcov-Brog H, Ben-Dov T, Glaich O, Liber D, Bornstein Y, Goltseker K, Ben-Bezalel R, Pavlovsky M, Golan T, Spitzer L, Matz H, Gonen P, Percik R, Leibou L, Perluk T, Ast G, Frand J, Brenner R, Ziv T, Khaled M, Ben-Eliyahu S, Barak S, Karnieli-Miller O, Levin E, Gepner Y, Weiss R, Pfluger P, Weller A, Levy C. Food-seeking behavior is triggered by skin ultraviolet exposure in males. Nature Metabolism. 2022 Jul;4(7):883-900. doi: 10.1038/s42255-022-00587-9. Epub 2022 Jul 11. PMID: 35817855; PMCID: PMC9314261.  PDF

Agbarya A, Sarel I, Ziv-Baran T, Agranat S, Schwartz O, Shai A, Nordheimer S, Fenig S, Shechtman Y, Kozlener E, Taha T, Nasrallah H, Parikh R, Elkoshi N, Levy C, Khoury R, Brenner R. Efficacy of the mRNA-Based BNT162b2 COVID-19 Vaccine in Patients with Solid Malignancies Treated with Anti-Neoplastic Drugs. Cancers (Basel). 2021 Aug 20;13(16):4191. doi: 10.3390/cancers13164191. PMID: 34439346; PMCID: PMC8391288.

Parikh R, Sorek E, Parikh S, Michael K, Bikovski L, Tshori S, Shefer G, Mingelgreen S, Zornitzki T, Knobler H, Chodick G, Mardamshina M, Boonman A, Kronfeld-Schor N, Bar-Joseph H, Ben-Yosef D, Amir H, Pavlovsky M, Matz H, Ben-Dov T, Golan T, Nizri E, Liber D, Liel Y, Brenner R, Gepner Y, Karnieli-Miller O, Hemi R, Shalgi R, Kimchi T, Percik R, Weller A, Levy C. Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior. Cell Reports. 2021 Aug 24;36(8):109579. doi: 10.1016/j.celrep.2021.109579. PMID: 34433056; PMCID: PMC8411113. Selected for Cell Reports cover, August 2021. PDF

Ofir-Birin Y, Ben Ami Pilo H, Cruz Camacho A, Rudik A, Rivkin A, Revach OY, Nir N, Block Tamin T, Abou Karam P, Kiper E, Peleg Y, Nevo R, Solomon A, Havkin-Solomon T, Rojas A, Rotkopf R, Porat Z, Avni D, Schwartz E, Zillinger T, Hartmann G, Di Pizio A, Quashie NB, Dikstein R, Gerlic M, Torrecilhas AC, Levy C, Nolte-'t Hoen ENM, Bowie AG, Regev-Rudzki N. Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration. Nature Communications. 2021 Aug 11;12(1):4851. doi: 10.1038/s41467-021-24997-7. PMID: 34381047; PMCID: PMC8357946

Sheinboim D, Parikh S, Parikh R, Menuchin A, Shapira G, Kapitansky O, Elkoshi N, Ruppo S, Shaham L, Golan T, Elgavish S, Nevo Y, Bell RE, Malcov H, Shomron N, Taub JW, Izraeli S, Levy C. Slow transcription of the 99a/let-7c/125b-2 cluster results in differential miRNA expression and promotes melanoma phenotypic plasticity. J Invest Dermatol. 2021 Jun 26:S0022-202X(21)01406-8. doi: 10.1016/j.jid.2021.03.036. Epub ahead of print. PMID: 34186058. PDF

Netanely D, Leibou S, Parikh R, Stern N, Vaknine H, Brenner R, Amar S, Factor RH, Perluk T, Frand J, Nizri E, Hershkovitz D, Zemser-Werner V, Levy C, Shamir R. Classification of node-positive melanomas into prognostic subgroups using keratin, immune, and melanogenesis expression patterns. Oncogene. 2021 Mar;40(10):1792-1805. doi: 10.1038/s41388-021-01665-0. Epub 2021 Feb 9. PMID: 33564068; PMCID: PMC7946641. PDF

Gilat N, Torchinsky D, Margalit S, Michaeli Y, Avraham S, Sharim H, Elkoshi N, Levy C, Zirkin S, Ebenstein Y. Rapid Quantification of Oxidation and UV Induced DNA Damage by Repair Assisted Damage Detection-(Rapid RADD). Anal Chem. 2020 Jul 21;92(14):9887-9894. doi: 10.1021/acs.analchem.0c01393. Epub 2020 Jul 8. PMID: 32578422.

Glaich O, Parikh S, Bell RE, Mekahel K, Donyo M, Leader Y, Shayevitch R, Sheinboim D, Yannai S, Hollander D, Melamed Z, Lev-Maor G, Ast G, Levy C. DNA methylation directs microRNA biogenesis in mammalian cells. Nature Communications. 2019 Dec 11;10(1):5657. doi: 10.1038/s41467-019-13527-1. PMID: 31827083; PMCID: PMC6906426.

Golan T, Parikh R, Jacob E, Vaknine H, Zemser-Werner V, Hershkovitz D, Malcov H, Leibou S, Reichman H, Sheinboim D, Percik R, Amar S, Brenner R, Greenberger S, Kung A, Khaled M, Levy C. Adipocytes sensitize melanoma cells to environmental TGF-β cues by repressing the expression of miR-211. Science Signaling. 2019 Jul 23;12(591):eaav6847. doi: 10.1126/scisignal.aav6847. PMID: 31337739. Selected for Science Signaling cover, July 2019. PDF

Golan T, Levy C. Negative Regulatory Loop between Microphthalmia-Associated Transcription Factor (MITF) and Notch Signaling. Int J Mol Sci. 2019 Jan 29;20(3):576. doi: 10.3390/ijms20030576. PMID: 30699982; PMCID: PMC6387231.

Brenner R, Kivity S, Peker M, Reinhorn D, Keinan-Boker L, Silverman B, Liphsitz I, Kolitz T, Levy C, Shlomi D, Pillar G, Peled N. Increased Risk for Cancer in Young Patients with Severe Obstructive Sleep Apnea. Respiration. 2019;97(1):15-23. doi: 10.1159/000486577. Epub 2018 Nov 12. PMID: 30419556.

Raz Y, Cohen N, Shani O, Bell RE, Novitskiy SV, Abramovitz L, Levy C, Milyavsky M, Leider-Trejo L, Moses HL, Grisaru D, Erez N. Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer. J Exp Med. 2018 Dec 3;215(12):3075-3093. doi: 10.1084/jem.20180818. Epub 2018 Nov 23. PMID: 30470719; PMCID: PMC6279405.

Malcov-Brog H, Alpert A, Golan T, Parikh S, Nordlinger A, Netti F, Sheinboim D, Dror I, Thomas L, Cosson C, Gonen P, Stanevsky Y, Brenner R, Perluk T, Frand J, Elgavish S, Nevo Y, Rahat D, Tabach Y, Khaled M, Shen-Orr SS, Levy C. UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems. Molecular Cell. 2018 Nov 1;72(3):444-456.e7. doi: 10.1016/j.molcel.2018.09.022. Epub 2018 Oct 25. PMID: 30401431; PMCID: PMC6224604. Selected for Molecular Cell cover, November 2018 and for Molecular Cell Early Press, October 2018. PDF

Nordlinger A, Dror S, Elkahloun A, Del Rio J, Stubbs E, Golan T, Malcov H, Pricket TD, Cronin JC, Parikh S, Labes S, Thomas L, Yankovitz G, Tabach Y, Levy C, Samuels Y, Khaled M. Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4. J Invest Dermatol. 2018 Oct;138(10):2216-2223. doi: 10.1016/j.jid.2018.03.1524. Epub 2018 Apr 19. PMID: 29679610.

Cohen-Tayar Y, Cohen H, Mitiagin Y, Abravanel Z, Levy C, Idelson M, Reubinoff B, Itzkovitz S, Raviv S, Kaestner KH, Blinder P, Elkon R, Ashery-Padan R. Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development. Development. 2018 Aug 9;145(15):dev163691. doi: 10.1242/dev.163691. PMID: 29986868.

Amar D, Vizel A, Levy C, Shamir R. ADEPTUS: a discovery tool for disease prediction, enrichment and network analysis based on profiles from many diseases. Bioinformatics. 2018 Jun 1;34(11):1959-1961. doi: 10.1093/bioinformatics/bty027. PMID: 29360930.

Brenner R, Ben-Zvi I, Shinar Y, Liphshitz I, Silverman B, Peled N, Levy C, Ben-Chetrit E, Livneh A, Kivity S. Familial Mediterranean Fever and Incidence of Cancer: An Analysis of 8,534 Israeli Patients With 258,803 Person-Years. Arthritis Rheumatol. 2018 Jan;70(1):127-133. doi: 10.1002/art.40344. Epub 2017 Dec 7. PMID: 28992365.

Sheinboim D, Maza I, Dror I, Parikh S, Krupalnik V, Bell RE, Zviran A, Suita Y, Hakim O, Mandel-Gutfreund Y, Khaled M, Hanna JH, Levy C. OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs. Nat Commun. 2017 Oct 18;8(1):1022. doi: 10.1038/s41467-017-01122-1. PMID: 29044103; PMCID: PMC5647326. PDF

Dror S, Sander L, Schwartz H, Sheinboim D, Barzilai A, Dishon Y, Apcher S, Golan T, Greenberger S, Barshack I, Malcov H, Zilberberg A, Levin L, Nessling M, Friedmann Y, Igras V, Barzilay O, Vaknine H, Brenner R, Zinger A, Schroeder A, Gonen P, Khaled M, Erez N, Hoheisel JD, Levy C. Melanoma miRNA trafficking controls tumour primary niche formation. Nat Cell Biol. 2016 Sep;18(9):1006-17. doi: 10.1038/ncb3399. Epub 2016 Aug 22. PMID: 27548915. Selected for Nature Cell Biology cover, September 2016, volume 18; covered in Nature Cell Biology News and Views: "Melanosomes foster tumour niche by activating CAFs", Susana García-Silva& Héctor Peinado; and highlighted in Nature reviews: "Melanoma melanosomes shape the stromal niche" David Killock. PDF

Levin L, Srour S, Gartner J, Kapitansky O, Qutob N, Dror S, Golan T, Dayan R, Brener R, Ziv T, Khaled M, Schueler-Furman O, Samuels Y, Levy C. Parkin Somatic Mutations Link Melanoma and Parkinson's Disease. J Genet Genomics. 2016 Jun 20;43(6):369-79. doi: 10.1016/j.jgg.2016.05.005. Epub 2016 May 13. PMID: 27297116.

Bell RE, Golan T, Sheinboim D, Malcov H, Amar D, Salamon A, Liron T, Gelfman S, Gabet Y, Shamir R, Levy C. Enhancer methylation dynamics contribute to cancer plasticity and patient mortality. Genome Res. 2016 May;26(5):601-11. doi: 10.1101/gr.197194.115. Epub 2016 Feb 23. PMID: 26907635; PMCID: PMC4864467. Covered in News and Views of PCMR "Switching enhancer methylation in metastatic melanoma”. PDF

Golan T, Messer AR, Amitai-Lange A, Melamed Z, Ohana R, Bell RE, Kapitansky O, Lerman G, Greenberger S, Khaled M, Amar N, Albrengues J, Gaggioli C, Gonen P, Tabach Y, Sprinzak D, Shalom-Feuerstein R, Levy C. Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF. Mol Cell. 2015 Aug 20;59(4):664-76. doi: 10.1016/j.molcel.2015.06.028. Epub 2015 Jul 30. PMID: 26236014. Covered in Cancer Discovery News: "Pinpointing Melanoma's Invasive Trigger", August 2015 and in Science Signaling News "Keratinocytes have the metastatic touch", September 2015. PDF

Dror I, Golan T, Levy C, Rohs R, Mandel-Gutfreund Y. A widespread role of the motif environment in transcription factor binding across diverse protein families. Genome Res. 2015 Sep;25(9):1268-80. doi: 10.1101/gr.184671.114. Epub 2015 Jul 9. PMID: 26160164; PMCID: PMC4561487.

Edri R, Yaffe Y, Ziller MJ, Mutukula N, Volkman R, David E, Jacob-Hirsch J, Malcov H, Levy C, Rechavi G, Gat-Viks I, Meissner A, Elkabetz Y. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors. Nat Commun. 2015 Mar 23;6:6500. doi: 10.1038/ncomms7500. PMID: 25799239; PMCID: PMC4383005.

Shaham O, Gueta K, Mor E, Oren-Giladi P, Grinberg D, Xie Q, Cvekl A, Shomron N, Davis N, Keydar-Prizant M, Raviv S, Pasmanik-Chor M, Bell RE, Levy C, Avellino R, Banfi S, Conte I, Ashery-Padan R. Pax6 regulates gene expression in the vertebrate lens through miR-204. PLoS Genet. 2013;9(3):e1003357. doi: 10.1371/journal.pgen.1003357. Epub 2013 Mar 14. PMID: 23516376; PMCID: PMC3597499.

Melamed Z, Levy A, Ashwal-Fluss R, Lev-Maor G, Mekahel K, Atias N, Gilad S, Sharan R, Levy C, Kadener S, Ast G. Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions. Mol Cell. 2013 Jun 27;50(6):869-81. doi: 10.1016/j.molcel.2013.05.007. Epub 2013 Jun 6. PMID: 23747012.

Bell RE, Khaled M, Netanely D, Schubert S, Golan T, Buxbaum A, Janas MM, Postolsky B, Goldberg MS, Shamir R, Levy C. Transcription factor/microRNA axis blocks melanoma invasion program by miR-211 targeting NUAK1. J Invest Dermatol. 2014 Feb;134(2):441-451. doi: 10.1038/jid.2013.340. Epub 2013 Aug 9. PMID: 23934065.  PDF

Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C*, Ruvkun G*. Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol. 2013 Oct 1;9:692. doi: 10.1038/msb.2013.50. PMID: 24084807; PMCID: PMC3817400. * indicates co-corresponding authors.

Janas MM, Khaled M, Schubert S, Bernstein JG, Golan D, Veguilla RA, Fisher DE, Shomron N, Levy C*, Novina CD*. Feed-forward microprocessing and splicing activities at a microRNA-containing intron. PLoS Genet. 2011 Oct;7(10):e1002330. doi: 10.1371/journal.pgen.1002330. Epub 2011 Oct 20. PMID: 22028668; PMCID: PMC3197686. * indicates co-corresponding authors.

Feige E, Yokoyama S, Levy C, Khaled M, Igras V, Lin RJ, Lee S, Widlund HR, Granter SR, Kung AL, Fisher DE. Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E924-33. doi: 10.1073/pnas.1106351108. Epub 2011 Sep 26. PMID: 21949374; PMCID: PMC3203758.

Golan D, Levy C, Friedman B, Shomron N. Biased hosting of intronic microRNA genes. Bioinformatics. 2010 Apr 15;26(8):992-5. doi: 10.1093/bioinformatics/btq077. Epub 2010 Feb 24. PMID: 20185406.

Levy C, Khaled M, Robinson KC, Veguilla RA, Chen PH, Yokoyama S, Makino E, Lu J, Larue L, Beermann F, Chin L, Bosenberg M, Song JS, Fisher DE. Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell. 2010 Jun 11;141(6):994-1005. doi: 10.1016/j.cell.2010.05.004. PMID: 20550935; PMCID: PMC2897150. Covered in News and Views of PCMR by Goding CR. Aug 2010.

Khaled M, Levy C, Fisher DE. Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit. Genes Dev. 2010 Oct 15;24(20):2276-81. doi: 10.1101/gad.1937710. PMID: 20952536; PMCID: PMC2956206. Covered in News and Views of PCMR by Ohanna M. et al. Nov 2010.

Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen PH, Li S, Fletcher AL, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD. Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell. 2010 Dec 10;40(5):841-9. doi: 10.1016/j.molcel.2010.11.020. Epub 2010 Nov 25. PMID: 21109473; PMCID: PMC3004467. Ranked 8th on the “must read” F1000 list, February 2011 and covered in News and Views of PCMR by Poenitzsch et al. April 2011.